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"1763 in the Ohio river valley you got Lord Jeffrey Amherst committing to written order an instruction to his subordinate Henry Bouquet, having been defeated by Pontiac Ottawa confederacy in the field. The order essentially says that they have been defeated militarily and is therefore necessary for Amherst forces to request a peace, to sue for peace from Pontiacs people. He instructs Bouquet to convene a parlay with the Indian leadership for that purpose. And as is the custom, as is common courtesy among native populations as was known to the Brits at that time, it would be necessary for those who requested the council to give gifts to those requested to attend. Make those gifts, Amherst says, items taken from a smallpox infirmary in order, I'm going to quote directly now, this isn't a paraphrase: 'in order that we may extirpate this execrable race'. Now key is on this last word, had he said that we might eradicate the opposing combatants, their military capacity, their warriors.. what ever term he wanted to use, it would have been biological warefare. But he didn't say anything about that, he said the 'race'. His intent was to use biological means, to use disease, quite explicitly so, to eradicate an entire population group. And Bouquet was also kind enough to commit to writing in his response the next day, I have done as instructed, dispersing three blankets, two handkerchiefs and sundry other items, hopefully, he says, they will have the desired result. They did.. the lowest estimate of the number of people who died of smallpox as a result of that little gesture of friendship and goodwill is a 100,000!"